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Article

Mutations and elevated transcriptional activity of conductin (AXIN2) in hepatoblastomas.

The Journal of pathology - 1 Dec 2004

Koch Arend, Weber Nina, Waha Andreas, Hartmann Wolfgang, Denkhaus Dorota, Behrens Jürgen, Birchmeier Walter, von Schweinitz Dietrich, Pietsch Torsten

Abstract excerpt

Hepatoblastoma (HB) is the most frequent malignant liver tumour of childhood. Most HBs develop sporadically but their incidence is highly elevated in patients with familial adenomatous polyposis coli (FAP). These patients carry germline mutations in the adenomatous polyposis coli (APC) tumour suppressor gene. APC forms a multi-protein complex involved in the WNT signalling pathway that controls the stability of...

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Share to Axin Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15538750
DOI: 10.1002/path.1662

Genes

APC
AXIN2
FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mutations and elevated transcriptional activity of conductin (AXIN2) in hepatoblastomas.PMID 15538750Read ↗

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