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Article

Antagonism between wild-type and mutant β-catenin controls hepatoblastoma differentiation via fascin-1

1 Feb 2023

Abstract excerpt

Background & Aims β-catenin is a well-known effector of the Wnt pathway, and a key player in cadherin-mediated cell adhesion. Oncogenic mutations of β-catenin are very frequent in paediatric liver primary tumours. Those mutations are mostly heterozygous, which allows the co-expression of wild-type (WT) and mutated β-catenins in tumour cells. We investigated the interplay between WT and mutated β-catenins in liver...

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PMID: 37153687
DOI: 10.1016/j.jhepr.2023.100691

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