Article
Somatic mutations of the APC gene in sporadic hepatoblastomas.
Cancer research - 15 Jul 1996
Oda H, Imai Y, Nakatsuru Y, Hata J, Ishikawa T
Abstract excerpt
Hepatoblastoma is a rare hepatic malignancy that occurs in children with an average age of 2 or 3 years and is known to be one of the extracolonic manifestations of familial adenomatous polyposis. Only a single hepatoblastoma with a germ-line mutation of the adenomatous polyposis coli (APC) gene...
Topics
- Base Sequence
- Child
- Child, Preschool
- DNA Primers
- DNA, Neoplasm
- Female
- Genes, APC
- Genes, Tumor Suppressor
- Hepatoblastoma
- Heterozygote
- Humans
- Infant
- Liver Neoplasms
- Male
- Molecular Sequence Data
- Mutation
- Proteins
- Sequence Deletion