Biallelic inactivation of the APC gene in hepatoblastoma.

Article

Biallelic inactivation of the APC gene in hepatoblastoma.

Cancer research - 1 Nov 1995

Kurahashi H, Takami K, Oue T, Kusafuka T, Okada A, Tawa A, Okada S, Nishisho I

Abstract excerpt

Familial adenomatous polyposis (FAP) is an inherited disorder caused by germline mutation of the adenomatous polyposis coli (APC) gene. Increased risk of hepatoblastoma (HBL) in FAP kindreds has been reported. To determine whether inactivation of the APC gene plays a role in development of HBL, 1...

Topics

Alleles
Base Sequence
Blotting, Southern
Gene Expression Regulation, Neoplastic
Genes, APC
Hepatoblastoma
Humans
Liver Neoplasms
Molecular Sequence Data
Point Mutation
Polymerase Chain Reaction

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