Article
Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas.
Oncogene - 18 Jul 2002
Taniguchi Ken, Roberts Lewis R, Aderca Ileana N, Dong Xiangyang, Qian Chiping, Murphy Linda M, Nagorney David M, Burgart Lawrence J, Roche Patrick C, Smith David I, Ross Julie A, Liu Wanguo
Abstract excerpt
Activation of Wnt signaling through beta-catenin mutations contributes to the development of hepatocellular carcinoma (HCC) and hepatoblastoma (HB). To explore the contribution of additional Wnt pathway molecules to hepatocarcinogenesis, we examined beta-catenin, AXIN1 and AXIN2 mutations in 73 HCCs and 27 HBs. beta-catenin mutations were detected in 19.2% (14 out of 73) HCCs and 70.4% (19 out of 27) HBs....
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