Article
Sporadic childhood hepatoblastomas show activation of beta-catenin, mismatch repair defects and p53 mutations.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2008
Curia Maria C, Zuckermann Michele, De Lellis Laura, Catalano Teresa, Lattanzio Rossano, Aceto Gitana, Veschi Serena, Cama Alessandro, Otte Jean-Bernard, Piantelli Mauro, Mariani-Costantini Renato, Cetta Francesco, Battista Pasquale
Abstract excerpt
Hepatoblastoma, a rare embryonic tumor that may arise sporadically or in the context of hereditary syndromes (familial adenomatous polyposis and Beckwith-Wiedemann's) is the most frequent liver cancer of childhood. Deregulation of the APC/beta-catenin pathway occurs in a consistent fraction of hepatoblastomas, with mutations in the APC and beta-catenin genes implicated in familial adenomatous polyposis-associated...
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