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Article

Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas.

International journal of cancer - 15 Jul 2007

Koch Arend, Hrychyk Aksana, Hartmann Wolfgang, Waha Anke, Mikeska Thomas, Waha Andreas, Schüller Ulrich, Sörensen Nils, Berthold Frank, Goodyer Cynthia G, Wiestler Otmar D, Birchmeier Walter, Behrens Jürgen, Pietsch Torsten

Abstract excerpt

Medulloblastomas (MBs) represent the most common malignant brain tumors in children. Most MBs develop sporadically in the cerebellum, but their incidence is highly elevated in patients with familial adenomatous polyposis coli. These patients carry germline mutations in the APC tumor suppressor gene. APC is part of a multiprotein complex involved in the Wnt signaling pathway that controls the stability of...

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Source

Identifiers

PMID: 17373666
DOI: 10.1002/ijc.22675

Genes

AXIN2
APC
AXIN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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