Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic mutations of beta-catenin play a crucial role in the tumorigenesis of sporadic hepatoblastoma.

Cancer letters - 28 Apr 2000

Jeng Y M, Wu M Z, Mao T L, Chang M H, Hsu H C

Abstract excerpt

Hepatoblastoma (HB) is the most common malignant hepatic tumor during early childhood. Its molecular pathogenesis is still poorly understood. Mutations of adenomatous polyposis coli (APC) gene have been identified in sporadic cases and in individuals associated with familial adenomatous polyposis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Cytoskeletal Proteins
Share to Gene Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatoblastoma

Share to Immunohistochemistry

Share to Infant, Newborn

Share to Liver Neoplasms

Share to Trans-Activators

Source

Identifiers

PMID: 10754205
DOI: 10.1016/s0304-3835(99)00433-4

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10754205-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic mutations of beta-catenin play a crucial role in the tumorigenesis of sporadic hepatoblastoma.PMID 10754205Read ↗

Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene.Semantic proximity Read ↗

Activation of beta-catenin in epithelial and mesenchymal hepatoblastomas.Semantic proximity Read ↗

Beta-catenin accumulation and mutation of the CTNNB1 gene in hepatoblastoma.Semantic proximity Read ↗

Sporadic childhood hepatoblastomas show activation of beta-catenin, mismatch repair defects and p53 mutations.Semantic proximity Read ↗

Nuclear localization of beta-catenin is an important prognostic factor in hepatoblastoma.Semantic proximity Read ↗

HGF/c-Met related activation of β-catenin in hepatoblastoma.Semantic proximity Read ↗

Nuclear accumulation of beta-catenin without an additional somatic mutation in coding region of the APC gene in hepatoblastoma from a familial adenomatous polyposis patient.Semantic proximity Read ↗

Diagnostic and prognostic impact of beta-catenin alterations in pediatric liver tumors.Semantic proximity Read ↗

APC germline hepatoblastomas demonstrate cisplatin-induced intratumor tertiary lymphoid structuresSemantic proximity Read ↗

Wnt/Beta-Catenin/Tcf Signaling: A Critical Pathway in Gastrointestinal TumorigenesisSemantic proximity Read ↗

Mutations and elevated transcriptional activity of conductin (AXIN2) in hepatoblastomas.Semantic proximity Read ↗

Somatic mutations of the APC gene in sporadic hepatoblastomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.