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Article

Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene.

Cancer research - 15 Jan 1999

Koch A, Denkhaus D, Albrecht S, Leuschner I, von Schweinitz D, Pietsch T

Abstract excerpt

Hepatoblastomas (HBs) are embryonal tumors affecting young children and representing the most frequent malignant liver tumors in childhood. The molecular pathogenesis of HB is poorly understood. Although most cases are sporadic, the incidence is highly elevated in patients with familial adenomatous polyposis coli. These patients carry germline mutations of the APC tumor suppressor gene. APC controls the...

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Source

Identifiers

PMID: 9927029

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene.PMID 9927029Read ↗

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APC germline hepatoblastomas demonstrate cisplatin-induced intratumor tertiary lymphoid structuresSemantic proximity Read ↗

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Hepatoblastoma and APC gene mutation in familial adenomatous polyposis.Semantic proximity Read ↗

Should children at risk for familial adenomatous polyposis be screened for hepatoblastoma and children with apparently sporadic hepatoblastoma be screened for APC germline mutations?Semantic proximity Read ↗

Germline APC mutations in hepatoblastomaSemantic proximity Read ↗

The ß-catenin-target Fascin-1, altering hepatocyte differentiation, is a new marker of immature cells in hepatoblastomasSemantic proximity Read ↗

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