Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene.

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Article

Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene.

Cancer research - 15 Jan 1999

Koch A, Denkhaus D, Albrecht S, Leuschner I, von Schweinitz D, Pietsch T

Abstract excerpt

Hepatoblastomas (HBs) are embryonal tumors affecting young children and representing the most frequent malignant liver tumors in childhood. The molecular pathogenesis of HB is poorly understood. Although most cases are sporadic, the incidence is highly elevated in patients with familial adenomato...

Topics

Adolescent
Adult
Amino Acid Sequence
Child
Child, Preschool
Cytoskeletal Proteins
Female
Genes, APC
Hepatoblastoma
Humans
Liver Neoplasms
Male
Middle Aged
Molecular Sequence Data
Mutation
Trans-Activators
Tumor Cells, Cultured
beta Catenin

Source

Open in PubMed

Identifiers

PMID: 9927029

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9927029-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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