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Article

Expression of p53 and 17p allelic loss in colorectal carcinoma.

Cancer research - 1 Apr 1992

Cunningham J, Lust J A, Schaid D J, Bren G D, Carpenter H A, Rizza E, Kovach J S, Thibodeau S N

Abstract excerpt

Mutations in the p53 gene are the most common genetic changes in cancer thus far. Many p53 mutations result in a protein product having a prolonged half-life compared to wild-type p53. The mutant protein is frequently detectable immunohistochemically, whereas the wild-type p53 present in normal cells is not. We examined 90 colorectal carcinomas for increased expression of p53 using 3 p53 specific monoclonal...

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PMID: 1551126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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