Expression of p53 and 17p allelic loss in colorectal carcinoma.

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Article

Expression of p53 and 17p allelic loss in colorectal carcinoma.

Cancer research - 1 Apr 1992

Cunningham J, Lust J A, Schaid D J, Bren G D, Carpenter H A, Rizza E, Kovach J S, Thibodeau S N

Abstract excerpt

Mutations in the p53 gene are the most common genetic changes in cancer thus far. Many p53 mutations result in a protein product having a prolonged half-life compared to wild-type p53. The mutant protein is frequently detectable immunohistochemically, whereas the wild-type p53 present in normal cells is not. We examined 90 colorectal carcinomas for increased expression of p53 using 3 p53 specific monoclonal...

Topics

Alleles
Amino Acid Sequence
Antibodies, Monoclonal
Base Sequence
Chromosomes, Human, Pair 17
Colorectal Neoplasms
DNA, Neoplasm
Gene Expression
Genes, p53
Humans
Immunohistochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Intestinal Mucosa

Molecular Sequence Data

Mutation

Oligodeoxyribonucleotides

Polymerase Chain Reaction

Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 1551126

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1551126-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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