Loss of 17p, mutation of the p53 gene, and overexpression of p53 protein in esophageal squamous cell carcinomas.

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Article

Loss of 17p, mutation of the p53 gene, and overexpression of p53 protein in esophageal squamous cell carcinomas.

Cancer research - 15 Feb 1993

Wagata T, Shibagaki I, Imamura M, Shimada Y, Toguchida J, Yandell D W, Ikenaga M, Tobe T, Ishizaki K

Abstract excerpt

We analyzed mutations of the p53 gene by single-strand conformation polymorphism analysis of polymerase chain reaction products and direct sequencing through all coding exons and exon-intron junctions in 32 cases with esophageal squamous cell carcinoma. Mutations were detected in 15 of 32 (47%) tumor samples, in which G:C to T:A transversions were rather frequent (33%). Previously, we reported deletion of...

Topics

Aged
Aged, 80 and over
Base Sequence
Carcinoma, Squamous Cell
Chromosome Deletion
Chromosomes, Human, Pair 17
Esophageal Neoplasms
Female
Genes, p53
Humans
Immunohistochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Molecular Sequence Data

Mutation

Polymorphism, Restriction Fragment Length

Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 8094033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8094033-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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