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Article

The TP53 tumour suppressor gene in colorectal carcinomas. I. Genetic alterations on chromosome 17.

British journal of cancer - 1 Jan 1993

Meling G I, Lothe R A, Børresen A L, Graue C, Hauge S, Clausen O P, Rognum T O

Abstract excerpt

In 231 colorectal carcinomas, allele variation at four restriction fragments length polymorphisms (RFLP) loci on chromosome 17 have been studied by Southern analysis. Heterozygous loss of the TP53 gene was found in 68% (129/189) of the carcinomas informative on both chromosome arms. In 41% (77/189) of the carcinomas the loss was found only on 17p. Two probes were used to detect alterations on 17p, pBHP53 and...

Topics

Adenocarcinoma
Adult
Aged
Aged, 80 and over
Alleles
Chromosome Deletion
Chromosomes, Human, Pair 17
Colorectal Neoplasms
Evaluation Studies as Topic
Female
Gene Amplification

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Tumor Suppressor

Humans

Male

Middle Aged

Polymorphism, Restriction Fragment Length

Source

Open in PubMed Open full text

Identifiers

PMID: 8094008
DOI: 10.1038/bjc.1993.14
PMCID: PMC1968229

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8094008-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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