Article
p53 allele losses, mutations and expression in breast cancer and their relationship to clinico-pathological parameters.
International journal of cancer - 20 Feb 1992
Thompson A M, Anderson T J, Condie A, Prosser J, Chetty U, Carter D C, Evans H J, Steel C M
Abstract excerpt
The p53 locus on the short arm of chromosome 17 at 17p 13.1 was examined for loss of heterozygosity, mutation, mRNA and protein expression in 60 primary breast cancers. Allele loss around the p53 locus was detected in 19/45 informative tumours (42%). p53 mutations in the evolutionarily conserved...
Topics
- Alleles
- Base Sequence
- Breast Neoplasms
- Chromosomes, Human, Pair 17
- DNA Mutational Analysis
- Gene Expression
- Heterozygote
- Humans
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- RNA, Messenger
- RNA, Neoplasm
- Tumor Suppressor Protein p53