Article
Multipoint linkage mapping using sibpairs: non-parametric estimation of trait effects with quantitative covariates.
Genetic epidemiology - 1 Jan 2005
Chiou Jeng-Min, Liang Kung-Yee, Chiu Yen-Feng
Abstract excerpt
Multipoint linkage analysis using sibpair designs remains a common approach to help investigators to narrow chromosomal regions for traits (either qualitative or quantitative) of interest. Despite its popularity, the success of this approach depends heavily on how issues such as genetic heterogeneity, gene-gene, and gene-environment interactions are properly handled. If addressed properly, the likelihood of...
Topics
- Algorithms
- Chromosome Mapping
- Chromosomes, Human, Pair 13
- Computer Simulation
- Genotype
- Humans
- Quantitative Trait Loci
- Siblings