Article
Interpreting analyses of continuous covariates in affected sibling pair linkage studies.
Genetic epidemiology - 1 Sept 2007
Schmidt Silke, Qin Xuejun, Schmidt Michael A, Martin Eden R, Hauser Elizabeth R
Abstract excerpt
Datasets collected for linkage analyses of complex human diseases often include a number of clinical or environmental covariates. In this study, we evaluated the performance of three linkage analysis methods when the relationship between continuous covariates and disease risk or linkage heterogeneity was modeled in three different ways: (1) The covariate distribution is determined by a quantitative trait locus...
Topics
- Computer Simulation
- Data Interpretation, Statistical
- Environment
- Family Health
- Genetic Linkage
- Genetic Predisposition to Disease
- Genotype
- Humans
- Models, Genetic
- Models, Theoretical
- Quantitative Trait Loci