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Article

A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test.

American journal of human genetics - 1 Feb 1998

Spielman R S, Ewens W J

Abstract excerpt

Linkage analysis with genetic markers has been successful in the localization of genes for many monogenic human diseases. In studies of complex diseases, however, tests that rely on linkage disequilibrium (the simultaneous presence of linkage and association) are often more powerful than those that rely on linkage alone. This advantage is illustrated by the transmission/disequilibrium test (TDT). The TDT requires...

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Identifiers

PMID: 9463321
DOI: 10.1086/301714
PMCID: PMC1376890

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A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test.PMID 9463321Read ↗

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Testing association and linkage using affected-sib-parent study designs.Semantic proximity Read ↗

A comparative study of sibship tests of linkage and/or association.Semantic proximity Read ↗

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Transmission disequilibrium test with discordant sib pairs when parents are available.Semantic proximity Read ↗

Accurate inference of relationships in sib-pair linkage studies.Semantic proximity Read ↗

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