A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test.

doi:10.1086/301714

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Article

A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test.

American journal of human genetics - 1 Feb 1998

Spielman R S, Ewens W J

Abstract excerpt

Linkage analysis with genetic markers has been successful in the localization of genes for many monogenic human diseases. In studies of complex diseases, however, tests that rely on linkage disequilibrium (the simultaneous presence of linkage and association) are often more powerful than those th...

Topics

Disease Susceptibility
Female
Genetic Carrier Screening
Genetic Diseases, Inborn
Genetic Linkage
Genomic Imprinting
Genotype
Humans
Linkage Disequilibrium
Male
Models, Genetic
Models, Statistical
Nuclear Family

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