Power of non-parametric linkage analysis in mapping genes contributing to human longevity in long-lived sib-pairs.

doi:10.1002/gepi.10304

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Article

Power of non-parametric linkage analysis in mapping genes contributing to human longevity in long-lived sib-pairs.

Genetic epidemiology - 1 Apr 2004

Tan Qihua, Zhao J H, Iachine I, Hjelmborg J, Vach W, Vaupel J W, Christensen K, Kruse T A

Abstract excerpt

This report investigates the power issue in applying the non-parametric linkage analysis of affected sib-pairs (ASP) [Kruglyak and Lander, 1995: Am J Hum Genet 57:439-454] to localize genes that contribute to human longevity using long-lived sib-pairs. Data were simulated by introducing a recentl...

Topics

Age Factors
Algorithms
Chromosome Mapping
Female
Gene Frequency
Genetic Linkage
Genotype
Humans
Longevity
Male
Models, Genetic
Siblings

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