Article
A statistical method for identification of polymorphisms that explain a linkage result.
American journal of human genetics - 1 Feb 2002
Sun Lei, Cox Nancy J, McPeek Mary Sara
Abstract excerpt
Suppose that many polymorphic sites have been identified and genotyped in a region showing strong linkage with a trait. A key question of interest is which site (or combination of sites) in the region influences susceptibility to the trait. We have developed a novel statistical approach to this p...
Topics
- Alleles
- Chromosome Mapping
- Computer Simulation
- Diabetes Mellitus, Type 2
- Female
- Gene Frequency
- Genetic Linkage
- Genetic Markers
- Genetic Predisposition to Disease
- Genotype
- Humans
- Linkage Disequilibrium
- Male
- Matched-Pair Analysis
- Microsatellite Repeats
- Models, Genetic
- Nuclear Family
- Pedigree