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Article

The interaction of p53 with replication protein A mediates suppression of homologous recombination.

Oncogene - 2 Dec 2004

Romanova Larisa Y, Willers Henning, Blagosklonny Mikhail V, Powell Simon N

Abstract excerpt

The tumor suppressor protein p53 is emerging as a central regulator of homologous recombination (HR) processes and DNA replication. P53 may downregulate HR through multiple mechanisms including the reported associations with the Rad51 and Rad54 recombinases, and the BLM and WRN helicases. Here, we investigated whether the interaction of p53 with human replication protein A (RPA) is necessary for the regulation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Recombination, Genetic

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Source

Identifiers

PMID: 15489903
DOI: 10.1038/sj.onc.1207982

Genes

BLM
WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The interaction of p53 with replication protein A mediates suppression of homologous recombination.PMID 15489903Read ↗

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