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Article

Inhibition of DNA replication factor RPA by p53.

Nature - 2 Sept 1993

Dutta A, Ruppert J M, Aster J C, Winchester E

Abstract excerpt

The tumour suppressor p53 specifically interferes with the onset of S phase. The mechanism of the growth suppression action of the protein is unclear, though recent evidence points to transcriptional activation and repression functions of the protein. A competing hypothesis suggests that p53 interacts with the DNA replication apparatus and directly interferes with DNA replication. The major evidence for this...

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Identifiers

PMID: 8361542
DOI: 10.1038/365079a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of DNA replication factor RPA by p53.PMID 8361542Read ↗

Loss of transactivation and transrepression function, and not RPA binding, alters growth suppression by p53.Semantic proximity Read ↗

The interaction of p53 with replication protein A mediates suppression of homologous recombination.Semantic proximity Read ↗

Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner.Semantic proximity Read ↗

A small molecule directly inhibits the p53 transactivation domain from binding to replication protein ASemantic proximity Read ↗

Repression of RNA Polymerase I Transcription by the Tumor Suppressor p53Semantic proximity Read ↗

Wild-type, but not mutant, human p53 proteins inhibit the replication activities of simian virus 40 large tumor antigen.Semantic proximity Read ↗

The SV40 Large T Antigen-p53 Complexes Bind and Activate the Insulin-like Growth Factor-I Promoter Stimulating Cell GrowthSemantic proximity Read ↗

p53 Protein Is a Suppressor of Papillomavirus DNA Amplificational ReplicationSemantic proximity Read ↗

The tumor suppressor protein p53 strongly alters human immunodeficiency virus type 1 replication.Semantic proximity Read ↗

Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance.Semantic proximity Read ↗

p53 Inhibits JC Virus DNA Replicationin Vivoand Interacts with JC Virus Large T-AntigenSemantic proximity Read ↗

The tumor suppressor p53 associates with gene coding regions and co-traverses with elongating RNA polymerase II in an in vivo model.Semantic proximity Read ↗

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