Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ATR-p53 restricts homologous recombination in response to replicative stress but does not limit DNA interstrand crosslink repair in lung cancer cells.

PloS one - 1 Jan 2011

Sirbu Bianca M, Lachmayer Sarah J, Wülfing Verena, Marten Lara M, Clarkson Katie E, Lee Linda W, Gheorghiu Liliana, Zou Lee, Powell Simon N, Dahm-Daphi Jochen, Willers Henning

Abstract excerpt

Homologous recombination (HR) is required for the restart of collapsed DNA replication forks and error-free repair of DNA double-strand breaks (DSB). However, unscheduled or hyperactive HR may lead to genomic instability and promote cancer development. The cellular factors that restrict HR processes in mammalian cells are only beginning to be elucidated. The tumor suppressor p53 has been implicated in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxia Telangiectasia Mutated Proteins
Share to Cross-Linking Reagents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

Share to Homologous Recombination

Share to Mitomycin

Share to Rad51 Recombinase

Share to Thymidine

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 21857991
DOI: 10.1371/journal.pone.0023053
PMCID: PMC3155521

Genes

ATR
ATM
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ATR-p53 restricts homologous recombination in response to replicative stress but does not limit DNA interstrand crosslink repair in lung cancer cells.PMID 21857991Read ↗

The interaction of p53 with replication protein A mediates suppression of homologous recombination.Semantic proximity Read ↗

p53 in recombination and repair.Semantic proximity Read ↗

Effect of wild-type, S15D and R175H p53 proteins on DNA end joining in vitro: potential mechanism of DNA double-strand break repair modulation.Semantic proximity Read ↗

Targeting of Rad51-dependent homologous recombination: implications for the radiation sensitivity of human lung cancer cell linesSemantic proximity Read ↗

The role of p53 in treatment responses of lung cancer.Semantic proximity Read ↗

Dissociation of p53-mediated suppression of homologous recombination from G1/S cell cycle checkpoint control.Semantic proximity Read ↗

Double bolt regulation of Rad51 by p53: a role for transcriptional repression.Semantic proximity Read ↗

Overexpression of mammalian Rad51 does not stimulate tumorigenesis while a dominant-negative Rad51 affects centrosome fragmentation, ploidy and stimulates tumorigenesis, in p53-defective CHO cells.Semantic proximity Read ↗

A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joiningSemantic proximity Read ↗

DNA Substrate Dependence of p53-Mediated Regulation of Double-Strand Break RepairSemantic proximity Read ↗

Influence of p53 tumor suppressor protein on bias of DNA repair and apoptotic response in human cells.Semantic proximity Read ↗

Homologous recombination induced by replication inhibition, is stimulated by expression of mutant p53.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.