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A small molecule directly inhibits the p53 transactivation domain from binding to replication protein A

24 Dec 2012

Abstract excerpt

Replication protein A (RPA), essential for DNA replication, repair and DNA damage signalling, possesses six ssDNA-binding domains (DBDs), including DBD-F on the N-terminus of the largest subunit, RPA70. This domain functions as a binding site for p53 and other DNA damage and repair proteins that contain amphipathic alpha helical domains. Here, we demonstrate direct binding of both ssDNA and the transactivation...

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PMID: 23267009
DOI: 10.1093/nar/gks1291

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