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Article

Overexpression of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability.

Nucleic acids research - 1 Mar 2010

Schild David, Wiese Claudia

Abstract excerpt

RAD51, a key protein in the homologous recombinational DNA repair (HRR) pathway, is the major strand-transferase required for mitotic recombination. An important early step in HRR is the formation of single-stranded DNA (ss-DNA) coated by RPA (a ss-DNA-binding protein). Displacement of RPA by RAD51 is highly regulated and facilitated by a number of different proteins known as the 'recombination mediators'. To...

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Share to DNA Repair
Share to Genes, p53
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19942681
DOI: 10.1093/nar/gkp1063
PMCID: PMC2831301

Genes

RAD51
BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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