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Article

Cellular functions of human RPA1. Multiple roles of domains in replication, repair, and checkpoints.

The Journal of biological chemistry - 4 Jul 2008

Haring Stuart J, Mason Aaron C, Binz Sara K, Wold Marc S

Abstract excerpt

In eukaryotes, the single strand DNA (ssDNA)-binding protein, replication protein A (RPA), is essential for DNA replication, repair, and recombination. RPA is composed of the following three subunits: RPA1, RPA2, and RPA3. The RPA1 subunit contains four structurally related domains and is responsible for high affinity ssDNA binding. This study uses a depletion/replacement strategy in human cells to reveal the...

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Share to DNA, Single-Stranded
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18469000
DOI: 10.1074/jbc.M800881200
PMCID: PMC2441558

Genes

RPA1
RPA2
RPA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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