Article
Loss of transactivation and transrepression function, and not RPA binding, alters growth suppression by p53.
Oncogene - 20 Jun 1996
Leiter L M, Chen J, Marathe T, Tanaka M, Dutta A
Abstract excerpt
The tumor suppressor protein p53 activates transcription from promoters with specific p53 binding elements, represses transcription from promoters without such elements and interacts with and inhibits the single-stranded DNA binding activity of the human DNA replication factor RPA. All these acti...
Topics
- Amino Acid Sequence
- Binding Sites
- Cell Division
- Cell Extracts
- DNA-Binding Proteins
- Genes, p53
- Herpes Simplex Virus Protein Vmw65
- Humans
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Phenylalanine
- Replication Protein A
- Transcription, Genetic
- Transcriptional Activation
- Tryptophan
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53