Article
Loss of transactivation and transrepression function, and not RPA binding, alters growth suppression by p53.
Oncogene - 20 Jun 1996
Leiter L M, Chen J, Marathe T, Tanaka M, Dutta A
Abstract excerpt
The tumor suppressor protein p53 activates transcription from promoters with specific p53 binding elements, represses transcription from promoters without such elements and interacts with and inhibits the single-stranded DNA binding activity of the human DNA replication factor RPA. All these activities involve the N terminal 70 amino acids of p53. Dissection of the domains of p53 which bind RPA suggest that...
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