Article
Dissociation of p53-mediated suppression of homologous recombination from G1/S cell cycle checkpoint control.
Oncogene - 3 Feb 2000
Willers H, McCarthy E E, Wu B, Wunsch H, Tang W, Taghian D G, Xia F, Powell S N
Abstract excerpt
The tumor suppressor p53 is considered as the guardian of the genome which is activated following genotoxic stress. In many cell types, p53 mediates G1 cell cycle arrest as the predominant cellular response. Inactivation of wild-type p53 leads to loss of G1/S checkpoint control and to genomic instability, including increased spontaneous homologous recombination (HR). To determine whether regulation of the G1/S...
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