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Article

p53 mutated in the transactivation domain retains regulatory functions in homology-directed double-strand break repair.

Oncogene - 26 Jun 2003

Boehden Gisa S, Akyüz Nuray, Roemer Klaus, Wiesmüller Lisa

Abstract excerpt

The tumor suppressor p53 transcriptionally transactivates cellular target genes that are implicated in growth control, apoptosis, and DNA repair. However, several studies involving p53 core domain mutants suggested that regulatory functions in recombinative repair do not require transcriptional transactivation and are separable from growth-regulation and apoptosis. Leu22 and Trp23 within the transactivation...

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PMID: 12821945
DOI: 10.1038/sj.onc.1206632

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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