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Article

A specific endoplasmic reticulum export signal drives transport of stem cell factor (Kitl) to the cell surface.

The Journal of biological chemistry - 31 Dec 2004

Paulhe Frédérique, Imhof Beat A, Wehrle-Haller Bernhard

Abstract excerpt

Stem cell factor, also known as Kit ligand (Kitl), belongs to the family of dimeric transmembrane growth factors. Efficient cell surface presentation of Kitl is essential for the migration, proliferation, and survival of melanocytes, germ cells, hemopoietic stem cells, and mastocytes. Here we demonstrate that intracellular transport of Kitl to the cell surface is driven by a motif in the cytoplasmic tail that...

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Identifiers

PMID: 15475566
DOI: 10.1074/jbc.M407813200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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