Article
Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection.
Proceedings of the National Academy of Sciences of the United States of America - 20 Oct 2015
Siggs Owen M, Popkin Daniel L, Krebs Philippe, Li Xiaohong, Tang Miao, Zhan Xiaoming, Zeng Ming, Lin Pei, Xia Yu, Oldstone Michael B A, Cornall Richard J, Beutler Bruce
Abstract excerpt
Endoplasmic reticulum (ER)-resident proteins are continually retrieved from the Golgi and returned to the ER by Lys-Asp-Glu-Leu (KDEL) receptors, which bind to an eponymous tetrapeptide motif at their substrate's C terminus. Mice and humans possess three paralogous KDEL receptors, but little is known about their functional redundancy, or if their mutation can be physiologically tolerated. Here, we present a...
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