Back to search

Article

Native and engineered human megakaryocytic extracellular vesicles for targeted non-viral cargo delivery to blood stem cells

2023-04-12

Abstract excerpt

Native and engineered extracellular vesicles (EVs) generated from human megakaryocytes (huMkEVs) or from the human megakaryocytic cell line CHRF (CHEVs) interact with tropism delivering their cargo to both human and murine hematopoietic stem and progenitor cells (HSPCs). 24 hours after intravenous infusion of huMkMPs into NOD- scid IL2Rγ null (NSG™) mice, they induced a nearly 50% increase in murine platelet cou...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
48215cb1-21e7-5c64-8f64-aa3aade07172
DOI
10.1101/2023.04.11.536479
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Native and engineered human megakaryocytic extracellular vesicles for targeted non-viral cargo delivery to blood stem cellsDOI 10.1101/2023.04.11.536479
Efficient non-viral delivery of macromolecules in human primary hematopoietic stem cells and lymphocytesSemantic proximity
Distinct profile of CD34+ cells and plasma-derived extracellular vesicles from triple-negative patients with Myelofibrosis reveals potential markers of aggressive disease.Semantic proximity
Extracellular Vesicles Derived From Adult and Fetal Bone Marrow Mesenchymal Stromal Cells Differentially Promote ex vivo Expansion of Hematopoietic Stem and Progenitor CellsSemantic proximity
A report on the International Society for Cell & Gene Therapy 2022 Scientific Signature Series, “Therapeutic advances with native and engineered human extracellular vesicles”Semantic proximity
Mesenchymal stromal cell-derived extracellular vesicles: novel approach in hematopoietic stem cell transplantationSemantic proximity
Targeted, safe, and efficient gene delivery to human hematopoietic stem and progenitor cells in vivo using the engineered AVID adenovirus vector platformSemantic proximity
Extracellular vesicles of stromal origin target and support hematopoietic stem and progenitor cells.Semantic proximity
Safety Evaluation of Long-term Administration of Umbilical Mesenchymal Stem Cell-Derived Extracellular VesiclesSemantic proximity
Bioactivity and miRNome Profiling of Native Extracellular Vesicles in Human Induced Pluripotent Stem Cell‐Cardiomyocyte DifferentiationSemantic proximity
Osteoblasts secrete miRNA-containing extracellular vesicles that enhance expansion of human umbilical cord blood cellsSemantic proximity
Induced Pluripotent Stem Cell-Derived Megakaryocytes and Platelets for Disease Modeling and Future Clinical Applications.Semantic proximity
Harnessing hydrodynamics for high-yield production of extracellular vesicles from stem cells spheroids with specific cargo profilingSemantic proximity
Select a neighboring publication to make it the new centre.