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Article

Stem cell factor presentation to c-Kit. Identification of a basolateral targeting domain.

The Journal of biological chemistry - 20 Apr 2001

Wehrle-Haller B, Imhof B A

Abstract excerpt

Stem cell factor (also known as mast cell growth factor and kit-ligand) is a transmembrane growth factor with a highly conserved cytoplasmic domain. Basolateral membrane expression in epithelia and persistent cell surface exposure of stem cell factor are required for complete biological activity in pigmentation, fertility, learning, and hematopoiesis. Here we show by site-directed mutagenesis that the cytoplasmic...

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Identifiers

PMID: 11152680
DOI: 10.1074/jbc.M008357200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Stem cell factor presentation to c-Kit. Identification of a basolateral targeting domain.PMID 11152680Read ↗

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Designing Motif-Engineered Receptors To Elucidate Signaling Molecules Important for Proliferation of Hematopoietic Stem Cells.Semantic proximity Read ↗

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Phosphorylation of the activation loop tyrosine 823 in c-Kit is crucial for cell survival and proliferation.Semantic proximity Read ↗

The presence of novel amino acids in the cytoplasmic domain of stem cell factor results in hematopoietic defects in Steel(17H) mice.Semantic proximity Read ↗

A ligand-receptor signaling threshold model of stem cell differentiation control: a biologically conserved mechanism applicable to hematopoiesisSemantic proximity Read ↗

Induction of lateral lumens through disruption of a monoleucine-based basolateral-sorting motif in betacellulin.Semantic proximity Read ↗

Kit ligand cytoplasmic domain is essential for basolateral sorting in vivo and has roles in spermatogenesis and hematopoiesis.Semantic proximity Read ↗

Direct binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation.Semantic proximity Read ↗

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