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Article

KIT D816V is dimerization-independent and activates downstream pathways frequently perturbed in mastocytosis.

British journal of haematology - 1 Sept 2023

Rajan Vinothkumar, Prykhozhij Sergey V, Pandey Aditya, Cohen Alejandro M, Rainey Jan K, Berman Jason N

Abstract excerpt

KIT, a type III tyrosine kinase receptor, plays a crucial role in haematopoietic development. The KIT receptor forms a dimer after ligand binding; this activates tyrosine kinase activity leading to downstream signal transduction. The D816V KIT mutation is extensively implicated in haematological malignancies, including mastocytosis and leukaemia. KIT D816V is constitutively active, but the molecular nuances that...

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Identifiers

PMID: 35245395
DOI: 10.1111/bjh.18116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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