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Article

MYCT1 controls environmental sensing in human haematopoietic stem cells

5 Jun 2024

Abstract excerpt

. Here we identify MYC target 1 (MYCT1; also known as MTLC) as a crucial human HSC regulator that moderates endocytosis and environmental sensing in HSCs. MYCT1 is selectively expressed in undifferentiated human haematopoietic stem and progenitor cells (HSPCs) and endothelial cells but becomes markedly downregulated during HSC culture. Lentivirus-mediated knockdown of MYCT1 prevented human fetal liver and cord...

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Share to Epigenetics and DNA Methylation
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PMID: 38839950
DOI: 10.1038/s41586-024-07478-x

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