Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Golgi Retention and Oncogenic Signaling of KIT Tyrosine Kinase in Gastrointestinal Stromal Tumor.

Sub-cellular biochemistry - 1 Jan 2026

Obata Yuuki, Nishida Toshirou

Abstract excerpt

KIT, a receptor protein tyrosine kinase (RTK), is localized in the plasma membrane and binds stem cell factor. A cancer-causing permanently active mutant of KIT (KITmut) accumulates aberrantly in intracellular compartments. Oncogenic RTK mutants other than KITmut also exhibit characteristic organelle localization, unlike their wild-type counterparts. However, the precise subcellular localization of RTKmut and its...

Topics

Join the communities discussing this publication.

Gastrointestinal Neoplasms
Gastrointestinal Stromal Tumors
Golgi Apparatus
Mutation
Protein Transport

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-kit

Signal Transduction

trans-Golgi Network

Source

Identifiers

PMID: 41718985
DOI: 10.1007/978-3-032-16833-7_16

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Golgi Retention and Oncogenic Signaling of KIT Tyrosine Kinase in Gastrointestinal Stromal Tumor.PMID 41718985Read ↗

Sustained Mutant KIT Activation in the Golgi Complex Is Mediated by PKC-θ in Gastrointestinal Stromal Tumors.Semantic proximity Read ↗

Golgi retention of KIT in gastrointestinal stromal tumour cells is phospholipase D activity-dependentSemantic proximity Read ↗

The aberrant localization of oncogenic kit tyrosine kinase receptor mutants is reversed on specific inhibitory treatment.Semantic proximity Read ↗

Neoplasia driven by mutant c-KIT is mediated by intracellular, not plasma membrane, receptor signaling.Semantic proximity Read ↗

Oncogenic Kit signalling on the Golgi is suppressed by blocking secretory trafficking with M-COPA in gastrointestinal stromal tumours.Semantic proximity Read ↗

Identification of novel pathogenic roles of BLZF1/ATF6 in tumorigenesis of gastrointestinal stromal tumor showing Golgi-localized mutant KIT.Semantic proximity Read ↗

Identification of novel pathogenic roles of BLZF1/ATF6 in tumorigenesis of gastrointestinal stromal tumor mediated by Golgi-localized mutant KITSemantic proximity Read ↗

Dance of The Golgi: Understanding Golgi Dynamics in Cancer MetastasisSemantic proximity Read ↗

KIT mutations induce intracellular retention and activation of an immature form of the KIT protein in gastrointestinal stromal tumors.Semantic proximity Read ↗

Normal and oncogenic forms of the receptor tyrosine kinase kit.Semantic proximity Read ↗

Golgi Complex: A Signaling Hub in CancerSemantic proximity Read ↗

Lipid rafts are required for Kit survival and proliferation signals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.