Article
Immunosuppression by Mutated Calreticulin Released from Malignant Cells.
Molecular cell - 20 Feb 2020
Liu Peng, Zhao Liwei, Loos Friedemann, Marty Caroline, Xie Wei, Martins Isabelle, Lachkar Sylvie, Qu Bo, Waeckel-Énée Emmanuelle, Plo Isabelle, Vainchenker William, Perez Franck, Rodriguez David, López-Otin Carlos, van Endert Peter, Zitvogel Laurence, Kepp Oliver, Kroemer Guido
Abstract excerpt
Mutations affecting exon 9 of the CALR gene lead to the generation of a C-terminally modified calreticulin (CALR) protein that lacks the KDEL endoplasmic reticulum (ER) retention signal and consequently mislocalizes outside of the ER where it activates the thrombopoietin receptor in a cell-autonomous fashion, thus driving myeloproliferative diseases. Here, we used the retention using selective hooks (RUSH) assay...
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