Article
Kit ligand cytoplasmic domain is essential for basolateral sorting in vivo and has roles in spermatogenesis and hematopoiesis.
Developmental biology - 15 Jan 2010
Deshpande Shayu, Agosti Valter, Manova Katia, Moore Malcolm A S, Hardy Matthew P, Besmer Peter
Abstract excerpt
Juxtamembrane signaling via the membrane growth factor KitL is critical for Kit mediated functions. KitL has a conserved cytoplasmic domain and has been shown to possess a monomeric leucine-dependent basolateral targeting signal. To investigate the consequences in vivo of impaired basolateral KitL targeting in polarized epithelial cells, we have mutated this critical leucine to alanine using a knock-in strategy....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.