Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neoplasia driven by mutant c-KIT is mediated by intracellular, not plasma membrane, receptor signaling.

Molecular and cellular biology - 1 Jan 2007

Xiang Zhifu, Kreisel Frederike, Cain Jennifer, Colson AnnaLynn, Tomasson Michael H

Abstract excerpt

Activating mutations in c-KIT are associated with gastrointestinal stromal tumors, mastocytosis, and acute myeloid leukemia. In attempting to establish a murine model of human KIT(D816V) (hKIT(D816V))-mediated leukemia, we uncovered an unexpected relationship between cellular transformation and intracellular trafficking. We found that transport of hKIT(D816V) protein was blocked at the endoplasmic reticulum in a...

Topics

Join the communities discussing this publication.

Bone Marrow Transplantation
Cell Membrane
Cell Proliferation
Gene Expression Regulation, Leukemic
Golgi Apparatus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia, Experimental

Mice, Inbred BALB C

Proto-Oncogene Proteins c-kit

Source

Open in PubMed Open full text

Identifiers

PMID: 17060458
DOI: 10.1128/MCB.01153-06
PMCID: PMC1800644

Genes

KIT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neoplasia driven by mutant c-KIT is mediated by intracellular, not plasma membrane, receptor signaling.PMID 17060458Read ↗

The aberrant localization of oncogenic kit tyrosine kinase receptor mutants is reversed on specific inhibitory treatment.Semantic proximity Read ↗

Role of intracellular tyrosines in activating KIT-induced myeloproliferative disease.Semantic proximity Read ↗

Golgi Retention and Oncogenic Signaling of KIT Tyrosine Kinase in Gastrointestinal Stromal Tumor.Semantic proximity Read ↗

KIT D816V is dimerization-independent and activates downstream pathways frequently perturbed in mastocytosis.Semantic proximity Read ↗

Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit.Semantic proximity Read ↗

Mastocytosis in mice expressing human Kit receptor with the activating Asp816Val mutationSemantic proximity Read ↗

Distinct cellular properties of oncogenic KIT receptor tyrosine kinase mutants enable alternative courses of cancer cell inhibition.Semantic proximity Read ↗

Normal and oncogenic forms of the receptor tyrosine kinase kit.Semantic proximity Read ↗

Pediatric mastocytosis-associated KIT extracellular domain mutations exhibit different functional and signaling properties compared with KIT-phosphotransferase domain mutations.Semantic proximity Read ↗

A transgenic zebrafish model expressing KIT-D816V recapitulates features of aggressive systemic mastocytosis.Semantic proximity Read ↗

A specific endoplasmic reticulum export signal drives transport of stem cell factor (Kitl) to the cell surface.Semantic proximity Read ↗

C-KIT mutation cooperates with full-length AML1-ETO to induce acute myeloid leukemia in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.