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Article

Chromatin domain boundaries delimited by a histone-binding protein in yeast.

The Journal of biological chemistry - 31 Dec 2004

Ferrari Sélène, Simmen Katia Carmine, Dusserre Yves, Müller Karin, Fourel Geneviève, Gilson Eric, Mermod Nicolas

Abstract excerpt

When located next to chromosomal elements such as telomeres, genes can be subjected to epigenetic silencing. In yeast, this is mediated by the propagation of the SIR proteins from telomeres toward more centromeric regions. Particular transcription factors can protect downstream genes from silencing when tethered between the gene and the telomere, and they may thus act as chromatin domain boundaries. Here we have...

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PMID: 15471882
DOI: 10.1074/jbc.M410346200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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