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Article

Insights into the impact of histone acetylation and methylation on Sir protein recruitment, spreading, and silencing in Saccharomyces cerevisiae.

Journal of molecular biology - 12 Sept 2008

Yang Bo, Britton Jeanette, Kirchmaier Ann L

Abstract excerpt

Silent chromatin formation in Saccharomyces cerevisiae begins with the recruitment of silent information regulator (Sir) proteins to silencers at the silent mating-type loci and to telomere ends. Next, Sir2/3/4 proteins propagate across these loci as histones are deacetylated by the NAD(+)-dependent histone deacetylase Sir2p, ultimately resulting in the cessation of transcription and in the loss of SET1- and...

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Share to Acetylation
Share to Gene Silencing
Share to Histones

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

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Source

Identifiers

PMID: 18619469
DOI: 10.1016/j.jmb.2008.06.059

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Insights into the impact of histone acetylation and methylation on Sir protein recruitment, spreading, and silencing in Saccharomyces cerevisiae.PMID 18619469Read ↗

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A nonhistone protein-protein interaction required for assembly of the SIR complex and silent chromatin.Semantic proximity Read ↗

Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation.Semantic proximity Read ↗

Role of the conserved Sir3-BAH domain in nucleosome binding and silent chromatin assembly.Semantic proximity Read ↗

Sir3 C-terminal domain involvement in the initiation and spreading of heterochromatin.Semantic proximity Read ↗

Simultaneous mutation of methylated lysine residues in histone H3 causes enhanced gene silencing, cell cycle defects, and cell lethality in Saccharomyces cerevisiae.Semantic proximity Read ↗

Hyperactivation of the silencing proteins, Sir2p and Sir3p, causes chromosome loss.Semantic proximity Read ↗

Chromosomal gradient of histone acetylation established by Sas2p and Sir2p functions as a shield against gene silencing.Semantic proximity Read ↗

Spreading of Sir3 protein in cells with severe histone H3 hypoacetylation.Semantic proximity Read ↗

Structural basis for the role of the Sir3 AAA+ domain in silencing: interaction with Sir4 and unmethylated histone H3K79.Semantic proximity Read ↗

A region of the nucleosome required for multiple types of transcriptional silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

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