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Article

SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast.

Genes & development - 1 Jan 1997

Strahl-Bolsinger S, Hecht A, Luo K, Grunstein M

Abstract excerpt

Yeast core telomeric heterochromatin can silence adjacent genes and requires RAP1, SIR2, SIR3, and SIR4 and histones H3 and H4 for this telomere position effect. SIR3 overproduction can extend the silenced domain. We examine here the nature of these multiprotein complexes. SIR2 and SIR4 were immunoprecipitated from whole-cell extracts. In addition, using formaldehyde cross-linking we have mapped SIR2, SIR4, and...

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Identifiers

PMID: 9000052
DOI: 10.1101/gad.11.1.83

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast.PMID 9000052Read ↗

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