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Article

Spreading of transcriptional repressor SIR3 from telomeric heterochromatin.

Nature - 5 Sept 1996

Hecht A, Strahl-Bolsinger S, Grunstein M

Abstract excerpt

Telomeric genes and the HM loci in saccharomyces cerevisiae are transcriptionally repressed and adopt a heterochromatin-like structure. The trans-acting factors RAP1, SIR3 and SIR4 are required for telomeric and HM silencing, and are thought to be chromosomal, but how they contribute to histone-d...

Topics

Chromosomes, Fungal
Cross-Linking Reagents
Fungal Proteins
GTP-Binding Proteins
Histones
Mutation
Precipitin Tests
Protein Binding
Saccharomyces cerevisiae
Silent Information Regulator Proteins, Saccharomyces cerevisiae
Telomere
Trans-Activators

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

rap GTP-Binding Proteins

Source

Identifiers

PMID: 8779721
DOI: 10.1038/383092a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8779721-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Spreading of transcriptional repressor SIR3 from telomeric heterochromatin.PMID 8779721Read ↗

SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast.Semantic proximity Read ↗

Sir3 C-terminal domain involvement in the initiation and spreading of heterochromatin.Semantic proximity Read ↗

Heterochromatin organization of a natural yeast telomere. Recruitment of Sir3p through interaction with histone H4 N terminus is required for the establishment of repressive structures.Semantic proximity Read ↗

Spreading of Sir3 protein in cells with severe histone H3 hypoacetylation.Semantic proximity Read ↗

Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1.Semantic proximity Read ↗

Genetic analysis of Rap1p/Sir3p interactions in telomeric and HML silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres.Semantic proximity Read ↗

Tethered Sir3p nucleates silencing at telomeres and internal loci in Saccharomyces cerevisiae.Semantic proximity Read ↗

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.Semantic proximity Read ↗

Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeast.Semantic proximity Read ↗

Sir2 deacetylates histone H3 lysine 56 to regulate telomeric heterochromatin structure in yeast.Semantic proximity Read ↗

A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.Semantic proximity Read ↗

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