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Article

Sir3-nucleosome interactions in spreading of silent chromatin in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Nov 2008

Buchberger Johannes R, Onishi Megumi, Li Geng, Seebacher Jan, Rudner Adam D, Gygi Steven P, Moazed Danesh

Abstract excerpt

Silent chromatin in Saccharomyces cerevisiae is established in a stepwise process involving the SIR complex, comprised of the histone deacetylase Sir2 and the structural components Sir3 and Sir4. The Sir3 protein, which is the primary histone-binding component of the SIR complex, forms oligomers in vitro and has been proposed to mediate the spreading of the SIR complex along the chromatin fiber. In order to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18794362
DOI: 10.1128/MCB.01210-08
PMCID: PMC2573294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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