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Article

Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation.

Nucleic acids research - 1 Jun 2009

Zhou Jing, Zhou Bo O, Lenzmeier Brian A, Zhou Jin-Qiu

Abstract excerpt

In the eukaryotic genome, transcriptionally silent chromatin tends to propagate along a chromosome and encroach upon adjacent active chromatin. The silencing machinery can be stopped by chromatin boundary elements. We performed a screen in Saccharomyces cerevisiae for proteins that may contribute to the establishment of a chromatin boundary. We found that disruption of histone deacetylase Rpd3p results in...

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Identifiers

PMID: 19372273
DOI: 10.1093/nar/gkp233
PMCID: PMC2699518

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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