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Article

Mutations in the nucleosome core enhance transcriptional silencing.

Molecular and cellular biology - 1 Mar 2005

Xu Eugenia Y, Bi Xin, Holland Michael J, Gottschling Daniel E, Broach James R

Abstract excerpt

Transcriptional silencing in Saccharomyces requires specific nucleosome modifications promoted in part by a complex of Sir proteins that binds to the modified nucleosomes. Recent evidence suggests that modifications of both the histone amino termini and the core domain of nucleosomes contribute to silencing. We previously identified histone H4 mutations affecting residues in the core of the nucleosome that yield...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15713639
DOI: 10.1128/MCB.25.5.1846-1859.2005
PMCID: PMC549373

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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