Bromodomains mediate an acetyl-histone encoded antisilencing function at heterochromatin boundaries.

doi:10.1016/s1097-2765(03)00035-2

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Article

Bromodomains mediate an acetyl-histone encoded antisilencing function at heterochromatin boundaries.

Molecular cell - 1 Feb 2003

Ladurner Andreas G, Inouye Carla, Jain Rajan, Tjian Robert

Abstract excerpt

Bromodomains bind acetylated histone H4 peptides in vitro. Since many chromatin remodeling complexes and the general transcription factor TFIID contain bromodomains, they may link histone acetylation to increased transcription. Here we show that yeast Bdf1 bromodomains recognize endogenous acetyl-histone H3/H4 as a mechanism for chromatin association in vivo. Surprisingly, deletion of BDF1 or a Bdf1 mutation that...

Topics

Acetylation
Down-Regulation
Genes, Fungal
Heterochromatin
Histones
Hydrogen Bonding
Models, Biological
Mutation
Protein Binding
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Silent Information Regulator Proteins, Saccharomyces cerevisiae
Transcription Factor TFIID
Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 12620225
DOI: 10.1016/s1097-2765(03)00035-2

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