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Article

High-resolution protein-DNA contacts for the yeast RNA polymerase II general transcription machinery.

Biochemistry - 12 Oct 2004

Chen Bo-Shiun, Mandal Subhrangsu S, Hampsey Michael

Abstract excerpt

We used site-specific protein-DNA photo-cross-linking to define contact points between Saccharomyces cerevisiae RNA polymerase II (RNAP II) and the general transcription factors TBP, TFIIB, and TFIIF on promoter DNA. We present three key findings: (i) the overall pattern of cross-link sites is remarkably similar between the yeast and the previously described human system, even though transcription initiates...

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Source

Identifiers

PMID: 15461446
DOI: 10.1021/bi048993r

Genes

TBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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