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Article

Functional interaction between TFIIB and the Rpb2 subunit of RNA polymerase II: implications for the mechanism of transcription initiation.

Molecular and cellular biology - 1 May 2004

Chen Bo-Shiun, Hampsey Michael

Abstract excerpt

The general transcription factor TFIIB is required for accurate initiation, although the mechanism by which RNA polymerase II (RNAP II) identifies initiation sites is not well understood. Here we describe results from genetic and biochemical analyses of an altered form of yeast TFIIB containing an arginine-78 --> cysteine (R78C) replacement in the "B-finger" domain. TFIIB R78C shifts start site selection...

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Identifiers

PMID: 15082791
DOI: 10.1128/MCB.24.9.3983-3991.2004
PMCID: PMC387735

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional interaction between TFIIB and the Rpb2 subunit of RNA polymerase II: implications for the mechanism of transcription initiation.PMID 15082791Read ↗

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