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Article

Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389.

Molecular and cellular biology - 1 Oct 2004

Bruins Wendy, Zwart Edwin, Attardi Laura D, Iwakuma Tomoo, Hoogervorst Esther M, Beems Rudolf B, Miranda Barbara, van Oostrom Conny T M, van den Berg Jolanda, van den Aardweg Gerard J, Lozano Guillermina, van Steeg Harry, Jacks Tyler, de Vries Annemieke

Abstract excerpt

Phosphorylation is important for p53 protein stabilization and activation after DNA damage. Serine 389 of p53 is specifically phosphorylated after UV irradiation, whereas gamma radiation activates p53 through a different pathway. To study the in vivo significance of p53 phosphorylation at serine 389, we generated a physiological mouse model in which p53 phosphorylation at serine 389 is abolished by alanine...

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Identifiers

PMID: 15456863
DOI: 10.1128/MCB.24.20.8884-8894.2004
PMCID: PMC517897

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Source receipt: pubmed, retrieved 7 Sept 2026.

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