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Article

Serine phosphorylation in the NH2 terminus of p53 facilitates transactivation.

Cancer research - 1 Jun 1995

Mayr G A, Reed M, Wang P, Wang Y, Schweds J F, Tegtmeyer P

Abstract excerpt

Murine tumor suppressor p53 is phosphorylated in the NH2-terminal transactivating domain at serines 9, 18, and 37. Change of any one of these serines to either alanine or aspartic acid did not alter p53 suppression of transformation of rat embryo fibroblasts by activated ras and E1A. Change of any two of these serines to alanines, however, led to a significant decrease in suppressor function. Substitution of...

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PMID: 7757994

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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