Article
Serine phosphorylation in the NH2 terminus of p53 facilitates transactivation.
Cancer research - 1 Jun 1995
Mayr G A, Reed M, Wang P, Wang Y, Schweds J F, Tegtmeyer P
Abstract excerpt
Murine tumor suppressor p53 is phosphorylated in the NH2-terminal transactivating domain at serines 9, 18, and 37. Change of any one of these serines to either alanine or aspartic acid did not alter p53 suppression of transformation of rat embryo fibroblasts by activated ras and E1A. Change of an...
Topics
- Alanine
- Animals
- Aspartic Acid
- Base Sequence
- Binding Sites
- Cell Nucleus
- DNA
- Gene Expression
- Mice
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Rats
- Sensitivity and Specificity
- Serine
- Transcriptional Activation
- Transformation, Genetic
- Tumor Suppressor Protein p53