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Article

Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis.

Cell death and differentiation - 1 Jan 2018

Castrogiovanni Cédric, Waterschoot Béranger, De Backer Olivier, Dumont Patrick

Abstract excerpt

The tumor suppressor p53 is a key regulator of apoptosis induced by various cellular stresses. p53 can induce apoptosis by two mechanisms. First, p53 acts as a transcription factor inducing and repressing pro-apoptotic and anti-apoptotic targets genes, respectively. Second, p53 is able to translocate to the mitochondria, where it interacts with BCL-2 family members to induce membrane permeabilization and...

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Identifiers

PMID: 28937686
DOI: 10.1038/cdd.2017.143
PMCID: PMC5729520

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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